General Information

  • ID:  hor006423
  • Uniprot ID:  P35807
  • Protein name:  Adipokinetic hormone precursor-related peptide beta chain
  • Gene name:  NA
  • Organism:  Schistocerca nitens (Vagrant locust) (Gray bird grasshopper)
  • Family:  AKH/HRTH/RPCH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007629 flight behavior
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YADPNADPMAFLYKLIQIEARKLAGCSN
  • Length:  28(34-61)
  • Propeptide:  MRQGCALTLMLLVVVCAALSAAQLNFSTGWGRRYADPNADPMAFLYKLIQIEARKLAGCSN
  • Signal peptide:  MRQGCALTLMLLVVVCAALSAA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  26-26
  • Structure ID:  AF-P35807-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006423_AF2.pdbhor006423_ESM.pdb

Physical Information

Mass: 359540 Formula: C139H218N36O41S2
Absent amino acids: HTVW Common amino acids: A
pI: 6.37 Basic residues: 3
Polar residues: 7 Hydrophobic residues: 11
Hydrophobicity: -13.21 Boman Index: -3157
Half-Life / Aliphatic Index: 2.8 hour Aliphatic Index: 87.5
Instability Index: 2337.86 Extinction Coefficient cystines: 2980
Absorbance 280nm: 110.37

Literature

  • PubMed ID:  2294116
  • Title:  The structurally similar neuropeptides adipokinetic hormone I and II are derived from similar, very small mRNAs.
  • PubMed ID:  3947348
  • Title:  Sequence analyses of adipokinetic hormones II from corpora cardiaca of Schistocerca nitans, Schistocerca gregaria, and Locusta migratoria by